Ultrasound-Promoted One-Pot, Three-Component Synthesis of Spiro[indoline-3,1'-pyrazolo[1,2-b]phthalazine] Derivatives

Ultrasound-promoted one-pot, three-component synthesis of spiro[indoline-3,1'-pyrazolo[1,2-b]phthalazine] derivatives.

A series of 3'-aminospiro[indoline-3,1'-pyrazolo[1,2-b]phthalazine]-2,5',10'-trione derivatives have been synthesized by a one-pot three-component reaction of isatin, malononitrile or ethyl cyanoacetate and phthalhydrazide catalyzed by piperidine under ultrasound irradiation. For comparison the reactions were carried out under both conventional and ultrasonic conditions. In general, improvement...

One-pot Three-component Synthesis of Phosphonate Derivatives

The stable phosphonate derivatives have easily synthesized by the reactions involving trialkyl(aryl) phosphites and dimethyl acetylenedicarboxylate in the presence of 4-nitrophenol and/or acid chlorides, dialkyl(aryl) phosphites and N-methylimidazole at 70 oC under solventfree conditions.

Ultrasound-promoted one-pot, four-component synthesis of pyridin-2(1H)-one derivatives.

An efficient one-pot synthesis of 1,6-diamino-2-oxo-1,2,3,4-tetrahydro- pyridine-3,5-dicarbonitrile derivatives by four-component piperidine-catalyzed reactions of a ketone, malononitrile, ethyl cyanoacetate and hydrazine hydrate under ultrasound irradiation is described. This method provides several advantages such as shorter reaction times, excellent yields, and a simple workup procedure.

one-pot three-component synthesis of phosphonate derivatives

An Efficient Synthesis of 4H-chromene Derivatives by a One-pot, Three-component Reaction

A facile and efficient one-pot, multicomponent synthesis of 4H-chromenes is reported, through the reaction of arylglyoxalmonohydrates with 1,3-diketones and malononitrile in eTEMPthanol in the presence of L-proline as a catalyst.